I'm not sure that's entirely true FC. In fact, this 2020 paper https://www.mdpi.com/1422-0067/21/20/7505/htm presents a comprehensive review of all oncolytic viruses in clinical trials published to date. A total of 120 trials were found.
It is compelling reading for anyone considering IMU. They describe methods of administration, including iv.
9.2. Intravenous Route
Intra lesional OV administration is currently by far the most commonly used delivery method. However many trials are also evaluating intravenous route of administration [44,45] due to its inherent advantages. Some of the advantages of IV route includes ease of administration, standardization of administered drug dose, potential for multiple and long term administration, and wider application of IV based treatment especially in smaller community clinics [46]. The key detriment to IV administration so far has been development of neutralizing antibodies and clearance of OV [47,48,49]. There are at least eight clinical studies that we can confirm which used IV route for OV administration.
I'm not sure that's entirely true FC. In fact, this 2020 paper...
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