You are not shy of having a go at people who are engaged in useful conversation about PAR are you? Anytime you want to actually contribute something constructive about PAR, positive or negative sentiment, rather than smart personal remarks, we are all ears...
Meanwhile for people actually interested in being informed on stocks they are interested in, some development overnight in biomarkers in OA, that may prove interesting to those imbued with thte science and mechanisms of action of PPS:
https://www.nih.gov/news-events/nih-research-matters/blood-biomarkers-knee-osteoarthritis"As few as six biomarkers in the serum samples could distinguish those who developed knee osteoarthritis from those who did not. Furthermore, they could do so up to 8 years before a clinical diagnosis was made. Predictions using these biomarkers were much more accurate than those based on age and BMI, knee pain, or preexisting osteoarthritis in the hip. Many of the biomarkers the team identified were from proteins involved in acute inflammation.
These results provide evidence that the damage to joint tissue that causes osteoarthritis begins at the molecular level, long before any damage can be seen by imaging. This damage may ultimately result from an acute inflammatory response that fails to shut off."
(20min delay)