Comparing requirements and recent results:
Primary Outcome Measures
Change in iron content as measured by brain MRI
the clinical responders on average had reduced accumulation of iron on MRI in the substantia nigra, putamen and globus pallidus.Secondary Outcome Measures1, indicating reduced disability on activities of daily living.
Change in Aggregating alpha-Synuclein Levels
Change in Neurofilament Light Chain Levels
stable levels of NFL, a marker of axonal injury, when compared to participants who declined.Change in Unified MSA Rating Scale (UMSARS) Score43% of participants showed improvement on the UMSARS
Change in SF-36 Score
TheSF-36 measures eight scales: physical functioning (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MH).
Sorry about the distorted message trying to copy and paste of phone at airport.
But above shows we have already ticked some of the boxes from the 202 trial.
And they are all measured from base line to 52wks
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