For the first time, I think, here is a video of Yale University research...... which is able to grow cancer ovarian cancer cells and live time test cancer drugs. Despite our market cap, only Novogens drug worked in this world first, ovarian cancer drug testing model.
This video from Yale is heavy going and discussion at the start and ends is most relevant....I scrolled forward to the relevant parts.
The video shows the extent of the Yale research. For our drug platform to apparently exclusively work in this model......just shows the extraordinary potential we are sitting on here.
https://www.jove.com/video/51815/murine-model-for-non-invasive-imaging-to-detect-monitor-ovarian
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Self explanatory summary of background:
"Over 10 years ago, Mor isolated ovarian cancer cells in his lab at Yale and provided the cells as a resource to pharmaceutical companies to develop better drugs. Companies would submit their compounds for testing, and Mor would test their ability to kill the cells. Novogen was one of the companies who submitted their drugs for testing by the Mor lab. "The Novogen drug, phenoxodiol, was the only drug that killed these cells," Mor says, which led to Yale and Novogen taking that drug into the clinic in women with late-stage ovarian cancer.
Dr. Graham Kelly, Novogen CEO, said, "Phenoxodiol ultimately failed, but the underlying family of drugs still was doing something that no other anti-cancer drugs were capable of, so we went back to square one and looked at what it would take to make these drugs more active in the clinic."
"We made the required breakthrough and now have a new generation of drugs that are thousands of times more powerful than the original drugs. But more importantly, we found that the changes we made now led to them killing cancer stem cells as well as the more prevalent somatic cancer cells," Kelly added.
At the same time that Novogen’s technology advanced, so did Mor's. His ability to identify, isolate and culture ovarian cancer stem cells is a major advance making it possible to test drugs before they go into the clinic to see if they are able to kill the full range of cells within a cancer.
"Chemotherapy is like cutting the grass," says Mor. "It doesn't kill the roots—the tumor-initiating cells. With this technology we can for the first time have a high degree of confidence in whether a drug is likely to be able to wipe out the full range of cancer cells within an ovarian cancer. And that is what we need to do in order to put patients into long-term if not permanent remission."
