MSB 4.69% $1.02 mesoblast limited

You wanna play with FIRE?, page-133

  1. 306 Posts.
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    I'm tired of people saying the trials failed.
    they didn't, some of you really need to stop being so ignorant.

    CHF didn't meet the primary endpoint of re-hospitalisation but it smashed the secondary endpoints at 60% reduced mortality how is that a fail? - I see this either getting approved straight up or approval with another confirmatory study.

    COVID ARDS - trial ended at the third analysis because DSMB said "may not reach primary endpoint of 43% reduction in mortality"
    firstly, since April, the UK has 10x the amount of COVID cases
    and 50% less deaths than it did in April, the standard of care is increasing to the point where it makes it hard to distinguish what is, and isn't working
    43% was also optimistic, MSCs role in repairing the damage don
    by COVID is what the secondary endpoints will be looking at, again not a fail if the trial shoes impressive lung repair
    Also, the DSMBs job is to ensure the trial continues its course (this point 43% reduction in mortality) the fact it ended means that in the third analysis it did not reach this number, so it's ending the trial, we may still may see 20-30% reduction in mortality while accelerating recovery (which is what we saw during the pilot study, i.e days of ventilators)

    srGVHD - again, not a fail, FDA want a "confirmatory study" before approval, who knows? We might see conditional approval based on the TA meeting
    Last edited by Pazy1: 23/12/20
 
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