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http://www.sciencedirect.com/science/article/pii/S1051044316300240
Results
Of 40 patients, 29 (72.5%) underwent TARE; the most common reasons for not undergoing TARE were attenuated hepatic arteries (5/11), high pulmonary shunt (4/11), and poor arterial flow (2/11). Patients who underwent ≤ 4 chemoembolizations to the TARE target tended to be more likely to undergo TARE after mapping than patients who had > 4 chemoembolizations (P = .056). Most common grade ≥ 3 toxicities were fatigue (9/29; 31%) and biochemical alterations (bilirubin [3/29; 10.3%], albumin [4/29; 13.8%], aspartate aminotransferase [5/29; 17.2%]). Of 27 patients treated with TARE with follow-up, responses were 11 (41%) complete response, 5 (19%) partial response, 2 (7%) stable disease, and 9 (33%) progressive disease. Median progression-free survival and overall survival were 90 days and 257 days.
Conclusions
TARE is safe and effective salvage therapy in patients after chemoembolization. In patients who have undergone > 4 chemoembolizations to the 90Y target, feasibility of TARE tends to be decreased.
Abbreviations
Table 1
- BCLC, Barcelona Clinic Liver Cancer
- HCC, hepatocellular carcinoma
- TARE,transarterial radioembolization
- 90Y, yttrium-90
Table 1.
Figure 1.
Table 2
Table 2.
Table 3
Table 3.
Figure 2.
- D.S.H. received grants from GE Healthcare (Little Chalfont, United Kingdom), Philips Healthcare (Best, The Netherlands), and Society of Interventional Radiology Foundation (Fairfax, Virginia). S.A.P. reports personal fees from BTG International (Ottawa, Ontario, Canada) and Guerbet (Villepinte, France) outside the submitted work. None of the other authors have identified a conflict of interest.
© 2016 SIR. Published by Elsevier Inc. All rights reserved.
- ⁎
Address correspondence to G.E.J.
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