Unfortunately, this is not PBT2 news, but one day there could be PBT2 wound dressing. But ATH has no interest in any of this kind of development and Queensland has more deep scientific interest, not so much in product development. This kind of activity should be sold out, IMO.

Adv Healthc Mater

. 2023 Jun 19;e2300312.

doi: 10.1002/adhm.202300312. Online ahead of print.

First-aid Hydrogel Wound Dressing with Reliable Hemostatic and Antibacterial Capability for Traumatic Injuries

Junyao Cheng ^{1 2}, Hufei Wang ^{3 4}, Jianpeng Gao ^{1 2}, Xiao Liu ^{1 2}, Ming Li ¹, Decheng Wu ⁵, Jianheng Liu ¹, Xing Wang ^{3 4}, Zheng Wang ¹, Peifu Tang ¹

Affiliations expand

• PMID: 37335228

DOI: 10.1002/adhm.202300312

Abstract

First-aid for severe traumatic injuries in the battlefield or pre-hospital environment, especially for skin defects or visceral rupture, remain a substantial medical challenge even in the context of the rapidly evolving modern medical technology. Hydrogel-based biomaterials are highly anticipated for excellent biocompatibility and bio-functional designability. Yet, inadequate mechanical and bio-adhesion properties limit their clinical application. To address these challenges, a kind of multifunctional hydrogel wound dressings are representatively developed with the collective multi-crosslinking advantages of dynamic covalent bonds, metal-catechol chelation, and hydrogen bonds. The mussel-inspired design and zinc oxide-enhanced cohesion strategy collaboratively reinforce the hydrogel's bio-adhesion in bloody or humoral environments. The pH-sensitive coordinate Zn²⁺ -catechol bond and dynamic Schiff base with reversible breakage and reformation equip the hydrogel dressing with excellent self-healing and on-demand removal properties. In vivo evaluation in a rat ventricular perforation model and MRSA-infected full-thickness skin defect model revealed excellent hemostatic, antibacterial and pro-healing effectiveness of the hydrogel dressing, demonstrating its great potential in dealing with severe bleeding and infected full-thickness skin wounds. This article is protected by copyright. All rights reserved.