Ann: Starpharma and Medicxi Partnership Petalion Therapeutics, page-155

more flaming

The chance Petalion achieve success somewhere between 3.5 and 4 out of 5 IMO. The Medicxi model for funding is staged and closely monitored. Progress payments are forwarded based on likelihood success, and also consideration is weighted as to how early stage the project is before coming to them for funding/investment.
Spl dendrimer platform is now well tested. The parameters/limitations are well known. SPL have been working with dendrimers for near two decades. Starpharma are one of only two companies to have successfully monetised therapy using dendrimers. The poly lysine dendrimer is the least toxic. Starpharma have proved they can manufacture at scalability and consistency, safety, tolerability and purity problems have been solved. They are not a startup. The platform DEP is now well proven.
The petalion initiative is looking to develop a treatment modality in oncology therapy for where there is unmet need. So a broad range of indications will be tested for probable success. Starpharma will be paid for the work they do to conjugate drugs for testing. This three way Starpharma Petalion Medicxi arrangement is ideal. Medicxi closely monitor likelihood of success and extend funding based on this. They can kill a project pretty quickly, which is good as you don’t want to waste time on poor prospects. But where our platform being further down the pipeline weight is given to that and can let trials run longer to give it a chance. Modern day drug developers use computational modeling and AI which can be pretty powerful tools in drug modeling to determine likelihood success to then determine worthiness progress tested in the clinic. Petalion would no doubt employ these technologies. They’ve been searching for a good while looking for the perfect partner with a platform that is Starpharmas DEP. It’s a good arrangement, will further validate our platform at no risk to us. It wasn’t our initiative but if they succeed we have a stake in that success. Nothing ventured nothing gained. IMO. I am not a scientist or physician. DYOR.