May I ask how, in your opinion, MSB should have gone about...

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    May I ask how, in your opinion, MSB should have gone about getting an appropriate historical control in a heteogeneous condition that's not particularly common and targeting a subset of that, a condition where grading and assessment have been historically subjective and unreliable?

    Also, may I ask what Incyte used for their historical control that resulted in FDA approval in a similar single-arm trial?
 
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