Ann: Positive AZD0466 clinical data presented by AstraZeneca, page-49

Fyi

Solid tumors (malignant) - An abnormal mass of tissue that usually does not contain cysts or liquid areas. Different types of solid tumors are named for the type of cells that form them. Examples of solid tumors are sarcomas, carcinomas, and lymphomas

Lymphoma - refers to types of cancer that begin in the lymphatic system (the various lymph glands around the body). Lymphomas are the sixth most common form of cancer overall

Multiple myeloma - is cancer of plasma cells in the bone marrow. The abnormal cells reduce the levels of healthy blood cells. Multiple myeloma causes weakening of the bones, anaemia, blood-clotting problems, kidney problems and an increased risk of infection.

There are three main types of blood cancers:

• Leukemia, a type of cancer found in your blood and bone marrow, is caused by the rapid production of abnormal white blood cells. The high number of abnormal white blood cells are not able to fight infection, and they impair the ability of the bone marrow to produce red blood cells and platelets.
• Lymphoma is a type of blood cancer that affects the lymphatic system, which removes excess fluids from your body and produces immune cells. Lymphocytes are a type of white blood cell that fight infection. Abnormal lymphocytes become lymphoma cells, which multiply and collect in your lymph nodes and other tissues. Over time, these cancerous cells impair your immune system.
• Myeloma is a cancer of the plasma cells. Plasma cells are white blood cells that produce disease- and infection-fighting antibodies in your body. Myeloma cells prevent the normal production of antibodies, leaving your body's immune system weakened and susceptible to infection.

Tumor lysis syndrome - (TLS) is a condition that occurs when a large number of cancer cells die within a short period, releasing their contents in to the blood. ... When cancer cells break down quickly in the body, levels of uric acid, potassium, and phosphorus rise faster than the kidneys can remove them. This causes TLS.