This is the quote btw from the WA Safety study about non absorption into bloodsteam
"....The finding that astodrimer sodium was not detected in the bloodstream following repeated nasal application is consistent with previous extensive nonclinical and clinical data showing lack of absorption into the blood- stream following topical application to mucosal membranes21,22. Therefore, systemic adverse events would not be expected to occur from nasal administration of astodrimer sodium, and there was no evidence of such events occurring in the current investigation...."
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