And thereby shows the sense of the WHO decision to encourage...

And thereby shows the sense of the WHO decision to encourage SARS-CoV-2 research with humanized mouse genome. Autopsy of mice provides excellent opportunity to disect organs after death AND to administer the virus to mice to perform studies. Both of those are not available to researchers with human participants and the ethics of placebo having nothing is also highly questionable..

Finding relevant human populations with controlled prior vaccination, boosting, masking, social contact exposure etc gets into ethics - can you say participants shouldn’t try to stop. I remember seeing articles about research in pacific island communities just to get appropriate controls.

Sanotise Canadian nitric oxide study in India was 6 doses 2 sprays each nostril a day which was a level of dosing that was unlikely to be accepted in other communities.