Vamorolone is a synthetic steroid, which is under development for the treatment of duchenne muscular dystrophy. Anti-inflammatory drugs of the corticosteroid class show a carbonyl or hydroxyl group on the C11 carbon of the steroid backbone.The lack of deleterious changes in bone turnover markers in patients with DMD treated with vamorolone suggests a possible loss of bone morbidities typically associated with glucocorticoidsGlucocorticoid treatment is the most common cause of osteoporosis; fractures occur in 30% to 50% of patients with DMD receiving long-term therapy.27
A recent retrospective study of an inception cohort of 403,337 patients newly diagnosed with rheumatoid arthritis, asthma/chronic obstructive pulmonary disease, inflammatory bowel disease, multiple sclerosis, lupus, and sarcoidosis found 72% to be prescribed glucocorticoids (52% at age <50 years).28 Use of glucocorticoids was strongly associated with increased rate of fractures,
A novel dissociative steroidal anti-inflammatory drug, vamorolone, showed evidence of efficacy and reduction of safety concerns typically seen with traditional glucocorticoids in a 48-patient, open-label, exploratory, multiple-ascending-dose study in young patients with DMD.
———————————- So comparing it to ATL1102..Vamorolone a dissociative steroid still has a great deal of side effects although not as much as corticosteroids... (bone fractures) Vamorolone is for young DMD patients (4-7 yrs old ) Atl1102 has No side effects...
Hope that helps Mispec..
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