Potent universal beta-coronavirus therapeutic activity mediated...

Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody Michael S. Piepenbrink, Et al. PLoS Pathog 18(7): e1010691. doi:10.1371/journal.ppat.1010691

“ a single 4 mg/kg intranasal dose to hamsters 12hours following infection with SARS-CoV-2 Delta protected them from weight loss, with therapeutic activity”.

“K18 hACE2 mice were treated with 1249A8 (40 mg/kg), 1213H7 (10 mg/kg), or isotype control mAb (40 mg/kg) either alone or in combination i.p. or i.n. as indicated and 24hours later challenged i.n. with 105 PFU SARS-CoV-2 Omicron (BEIR)”

Copyright: © 2022 Piepenbrink et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


where Is SPL study with mice and hamster get viraleze hours before challenge with virus? Has it been done but not worked good?