Yes definitely will be a factor in it for sure...this is why some protocols are IBW - Ideal Body Weight, they take the weight of the person into account.
"The amount of fat tissue in a person’s body increases the distribution space and thereby lowers the serum concentrations of fat soluble medications, which can in turn affect the effectiveness of the drug".
Ref:
https://stop.publichealth.gwu.edu/LFD-apr23
Yes definitely will be a factor in it for sure...this is why...
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