I have a theory that Viraleze could be an effective agent used to:
1. prevent sinusitis resulting from an episode of the common cold or flu and;
2. help treat chronic / recurrent sinusitis.
Acute and chronic sinusitis are very common conditions. I am a GP, and I see them very frequently. I, myself, tend to go on to develop acute bacterial sinusitis almost every time I suffer a cold.
If any fellow hotcopper users suspect some effect of VIRALEZE appearing to help with preventing or treating sinusitis, serendipitously, whilst using the spray (as per the approved indication in their country) to prevent a viral respiratory infection, please post their experience on this thread. Of course, this would be purely ANECDOTAL evidence, of interest, but not proving anything. Please post any negative impressions as well.
PLEASE NOTE: I am not asking people to use VIRALEZE in any way that differs from its approved indication in the country where they live. That would be me conducting research without gaining appropriate approvals. If you use VIRALEZE in any way other than its approved use (off-label), that is your decision alone.
I recognise that most of us on the SPL hotcopper forum are Australian and currently we cannot buy VIRALEZE, but please consider posting your experiences once VIRALEZE becomes more freely available.
The rationale for my theory:
SPL7013 (the active ingredient in VIRALEZE and in VIVAGEL) was incidentally found to be an effective agent for treatment and prevention of bacterial vaginosis, whilst in human trials testing its use as an antiviral agent in the female genital tract.
SPL7013 is an effective antiviral agent because its physicochemical properties (its high solubility and the physical size of the dendrimer molecule) allows it to dissolve/dissipate in a mucous membrane solution and then interfere with the spike proteins of multiple different viruses (including capsulated and non-encapsulated viruses and viruses of varying types). It has been found to act in a similar way against one bacteria (so far) as it also interferes with the binding of gardnerella vaginalis (the bacteria responsible for bacterial vaginosis) to the cells of the vaginal epithelium.
I think there is a reasonable chance that SPL7013 could also interfere with the binding of other pathogenic bacteria to the respiratory epithelium, thereby reducing the risk of developing bacterial sinusitis after a cold/flu and also helping to treat chronic sinusitis. I can't wait to one-day find out if my theory is correct!
Gumnut
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