WHO Solidarity Trial Results

WHO released the data from their mega Solidarity trial of 4 potential Covid treatment options (including Remdesivir) which i have summarized below:

• Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir (fixed-dose combination with Ritonavir) and Interferon-β1a
• COVID-19 patients were randomized equally between whichever study drugs were locally available and open control
• 11,266 adults were randomized, with 2750 allocated Remdesivir, 954 Hydroxychloroquine, 1411 Lopinavir, 651 Interferon plus Lopinavir, 1412 only Interferon, and 4088 no study drug
• Death rate ratios were: Remdesivir (301/2743 active vs 303/2708 control), Hydroxychloroquine (104/947 vs 84/906 control), Lopinavir (148/1399 vs 146/1372 control) and Interferon (243/2050 vs 216/2050 control)
• Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay

This study shows that there is currently no treatment that significantly reduces Covid-19 mortality. Note that the trial results do still need to be peer reviewed.

https://www.medrxiv.org/content/10.1101/2020.10.15.20209817v1